Toxic epidermal necrosis
https://en.wikipedia.org/wiki/Toxic_epidermal_necrolysis
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References
Stevens–Johnson Syndrome and Toxic Epidermal Necrolysis: A Review of Diagnosis and Management 34577817 NIH
Stevens-Johnson Syndrome (SJS) እና Toxic Epidermal Necrolysis (TEN) የቆዳ ትልቅ ንብረት የሚያስከትሉ ኒክሮሲስ እና ሞቅ የሚያጋጥሉ ሁኔታዎች ናቸው። በሕክምና ሂደት ውስጥ cyclophosphamide ለ SJS በጣም ውጤታማ ነው፤ በደም ውስጥ ያለው ኢሚውኖግሎቡሊን (IVIg) እና corticosteroids ጥምረት ለ SJS እና TEN ጉዳዮች በጣም ጥሩ ናቸው።
Stevens-Johnson Syndrome (SJS) and Toxic Epidermal Necrolysis (TEN) are rare diseases that are characterized by widespread epidermal necrosis and sloughing of skin. Regarding treatment, cyclosporine is the most effective therapy for the treatment of SJS, and a combination of intravenous immunoglobulin (IVIg) and corticosteroids is most effective for SJS/TEN overlap and TEN.
Toxic Epidermal Necrolysis: A Review of Past and Present Therapeutic Approaches 36469487Toxic epidermal necrolysis (TEN) በአንዳንድ መድሃኒቶች እና የበሽታ መከላከል ስርአቶች እንቅስቃሴ የሚፈጠር ከባድ የቆዳ ምላሽ ነው። ይህ ሁኔታ የውጭውን የቆዳ ሽፋን (epidermis) በከፍተኛ መጠን መነጠል እና ከ 30 % በላይ የሰውነት የገጽታ ክፍልን ይጎዳል። TEN የሞት ተገቢ አደገኛ ሁኔታ ነው፤ የሞት ተገቢ ደረጃ 20 % በላይ ነው፣ ብዙውን ጊዜ በኢንፌክሽን እና በአተነፋፈስ ችግር ይከሰታል። ምላሹን የሚያስከትል መድሃኒቶችን ማቆም፣ ድጋፍ ሰጪ እንክብካቤን መስጠት፣ እና ተጨማሪ ህክምናዎችን መተግበር ውጤቱን ሊያሻሽል ይችላል። በቅርቡ የተደረጉ ጥናቶች የተገለጹት እንደ Cyclophosphamide, TNF‑α factor, alpha inhibitors, ግሎቡሊን (glucobulin) እና ኮርቲኮስትሮይድ ያሉ መድሃኒቶች በTEN ምላሽ ላይ አጋዥ ሊሆኑ ይችላሉ።
Toxic epidermal necrolysis (TEN) is a serious skin reaction caused by certain medications and immune system activity, resulting in large-scale detachment of the outer skin layer (epidermis), affecting more than 30% of the body's surface. TEN has a mortality rate of over 20%, often due to infections and breathing difficulties. Stopping the medication causing the reaction, providing supportive care, and using additional treatments can improve the outcome. Recent studies have shown that drugs like cyclosporine, tumor necrosis factor alpha inhibitors, and a combination of intravenous immune globulin and corticosteroids can be helpful, based on randomized controlled trials and analyses of multiple studies.
Toxic Epidermal Necrolysis and Steven–Johnson Syndrome: A Comprehensive Review 32520664 NIH
Recent Advances: There is improved understanding of pain and morbidity with regard to the type and frequency of dressing changes. More modern dressings, such as nanocrystalline, are currently favored as they may be kept in situ for longer periods. The most recent evidence on systemic agents, such as corticosteroids and cyclosporine, and novel treatments, are also discussed.
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